Drug design: hiding in full view
نویسندگان
چکیده
منابع مشابه
Drug Design: Hiding in Full View
Compounds that can produce potent biological effects in cells encompass a variety of structural motifs. Many of these compounds share a structural feature that has rarely been noted. It is an allylic cluster of atoms, a 3-carbon chain with a double bond between two of the atoms and an oxygen atom at the other end. The oxygen can be in a hydroxyl group, or in an ether or ketal or ester linkage, ...
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The authors report the direct observation of a single asperity tungsten tip sliding on graphite by in situ transmission electron microscopy TEM nanomanipulation. The in situ TEM studies have confirmed that graphitic flakes transfer to a sliding tungsten probe, validating proposed friction mechanisms explaining the unique tribological properties of graphite. Wear of graphite was observed, typica...
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(3) Dr. P. M. Keir, M.B., M.R.C.P., Medical Registrar, National Heart Hospital. (4) Professor R. Hoffenberg, M.D., F.R.C.P., Professor of Medicine, University of Birmingham. (5) Professor D. L. Gardner, M.D., F.R.C.P.Ed., Professor of Pathology, Queen's University, Belfast. (6) Dr. E. B. Jarrett, M.B., F.R.C.P., Consultant Physician, Dorset County Hospital. (7) Dr. J. H. H. Macrae, M.B., Ch.B.,...
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ژورنال
عنوان ژورنال: Drug Development Research
سال: 2008
ISSN: 0272-4391,1098-2299
DOI: 10.1002/ddr.20223